Crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester
US6090972A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 19, 1999 |
| Grant date | Jul 18, 2000 |
| Priority date | — |
| Expiry date | Jul 19, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0613
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a method of cooling and crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester, which is a sweetening agent, commonly referred to as aspartame. An aspartame solution is cooled such that the solution is flown while being continuously in thermal contact with a coolant. As the cooling of the aspartame solution by the thermal contact with the coolant proceeds, the temperature difference between the aspartame solution and the coolant remains substantially constant. The coolant flows in the opposite direction as the aspartame solution flows and cools an upstream part of the aspartame solution as the coolant flows downstream.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.