Method and compositions for lipidization of hydrophilic molecules
US6093692A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 25, 1997 |
| Grant date | Jul 25, 2000 |
| Priority date | — |
| Expiry date | Sep 25, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/542
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Fatty acid derivatives of disulfide-containing compounds (for example, disulfide-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed for delivery of the compounds to mammalian cells. This modification markedly increases the absorption of the compounds by mammalian cells relative to the rate of absorption of the unconjugated compounds, as well as prolonging blood and tissue retention of the compounds. Moreover, the disulfide linkage in the conjugate is quite labile in vivo and thus facilitates intracellular or extracellular release of the intact compounds from the fatty acid moieties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.