Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF
US6093700A · kind A · utility
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Key dates
| Filing date | Feb 20, 1997 |
| Grant date | Jul 25, 2000 |
| Priority date | — |
| Expiry date | Feb 20, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/24171
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.