Substituted isoquinoline-3-carboxamides, their preparation and their use as pharmaceuticals

US6093730A · kind A · utility

Assignee

• Hoechst Marion Roussel Deutschland GmbH · DE

Inventors

• Klaus Weidmann · Kronberg, DE
• Karl-Heinz Baringhaus · Blieskastel, DE
• Georg Tschank · Frankfurt am Main, DE
• Ulrich Werner · Frankfurt am Main, DE

Key dates

• Filing date: Oct 19, 1998
• Grant date: Jul 25, 2000
• Expiry date: Oct 19, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel isoquinoline-3-carboxamides of the formula I: ##STR1## in which R.sub.1 is hydrogen or chlorine, R.sup.2 is hydrogen, alkyl, alkoxy, chlorine, trifluoromethyl, hydroxyl, or benzyloxy which is optionally substituted, or fluoroalkoxy of the formula O--[CH.sub.2 ].sub.x --C.sub.f H.sub.(2f+1-g) F.sub.g, where x=0 or 1, f=1-5, and g=1 to (2f+1), R.sup.3 is hydrogen, alkyl, alkoxy, fluorine, chlorine, cyano, trifluoromethyl, hydroxyl, or benzyloxy which is optionally substituted, or fluoroalkoxy of the above formula, R.sup.4 and R.sup.5 are hydrogen, alkyl, fluorine, chlorine, bromine, trifluoromethyl, cyano, alkoxy, or fluoroalkoxy of the above formula, including the physiologically active salts, are strong prolyl-4-hydroxylase inhibitors which do not cause steatosis.