Genetically engineered mice containing alterations in the gene encoding RXR
US6093873A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 19, 1997 |
| Grant date | Jul 25, 2000 |
| Priority date | — |
| Expiry date | Aug 19, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0393
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to mice which are genetically altered to be deficient in the normal expression of RXR.gamma., to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The invention further provides mice and cell lines which, in addition to being deficient in RXR.gamma., are genetically altered to be deficient in the expression of RXR.alpha. and/or RXR.beta.. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of RXR.gamma., or the normal expression thereof, is desirable.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.