Process for preparing chromanol derivatives

US6096907A · kind A · utility

Assignee

• BASF SE

Inventors

• Kai-Uwe Baldenius · Ludwigshafen, DE
• Bernhard Bockstiegel · Wasserburg am Inn, DE
• Hagen Jaedicke · Ludwigshafen, DE
• Detlef Ruff · Ludwigshafen, DE
• Carsten Siedenbiedel · Mannheim, DE
• Rainer Stürmer · Bad Dürkheim, DE

Key dates

• Filing date: Sep 14, 1999
• Grant date: Aug 1, 2000
• Expiry date: Sep 14, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing chromanol derivatives of the formula I ##STR1## where n is from 1 to 10, PA1 R.sup.1, R.sup.2, PA1 R.sup.3, R.sup.4 independently of one another are hydrogen or C.sub.1 -C.sub.4 alkyl, PA1 R.sup.5 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.6 -C.sub.10 aryl, C.sub.7 -C.sub.18 aralkyl, C.sub.7 -C.sub.18 alkylaryl, C.sub.1 -C.sub.22 acyl, or a group protecting the hydroxyl, by reduction of the corresponding 4-oxochromanol derivatives of the formula II ##STR2## comprises reacting the 4-oxochromanol derivatives of the formula II with metallic zinc in the presence of an acid or an acid mixture. Compounds of the formula I having C.sub.1 -C.sub.22 acyl as radical R.sup.5 can also be prepared by the above-described reduction of the compounds of the formula II with hydrogen as radical R.sup.5 and simultaneous or subsequent esterification.