Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6096909A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 13, 1997 |
| Grant date | Aug 1, 2000 |
| Priority date | — |
| Expiry date | Aug 13, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a taxoid of the formula (I) ##STR1## wherein R.sup.1 is 1-propenyl radical; PA1 R.sup.2 is a C.sub.3 -C.sub.5 branched alkyl radical; PA1 R.sup.3 and R.sup.4 are independently selected from hydrogen and hydroxyl protecting groups including functional groups which increase the water solubility of the taxoid antitumor agent; PA1 R.sup.5 represents a hydrogen or a hydroxyl protecting group; PA1 R.sup.6 represents an acyl radical, which are useful as antitumor agents or their precursors. A pharmaceutical composition having antineoplastic activity comprising the compound of formula (I) and a physiologically acceptable carrier and method of treatment are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.