Process for the preparation of thioether-substituted aromatic ketones
US6096929A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 6, 1999 |
| Grant date | Aug 1, 2000 |
| Priority date | — |
| Expiry date | Aug 6, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C201/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The preparation of aromatic ketones substituted with a thioether group at the ortho position is accomplished by the initial reaction of an aromatic nucleus substituted with a halide and an ortho nitro group with a nitroalkane in the presence of a hydroxide base. The resulting ortho-nitroalkyl nitroarene compound is converted to the corresponding ortho-nitroaryl ketone by an oxidative Nef reaction. The aromatic nitro group of the ortho-nitroaryl ketone is replaced with a thioether group by reaction with a thiolate anion, most preferably under phase-transfer conditions. Aromatic ketones may be used to prepare various pharmaceutical and herbicidal compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.