Spiro-piperidine derivatives as inhibitors of nitric oxide synthase
US6100246A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 8, 1999 |
| Grant date | Aug 8, 2000 |
| Priority date | — |
| Expiry date | May 8, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are provided novel compounds of formula (I) ##STR1## wherein A represents a benzo ring; a six membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms; or a five membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may be the same or different and are selected from O, N and S; and R.sup.1, R.sup.2, R.sup.3 and X are as defined in the Specification and pharmaceutically acceptable salts thereof and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment and prophylaxis of inflammatory disease and pain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.