Patent · US Expired

Method of inhibiting cancer growth

US6100248A · kind A · utility

21Cited by

7References

34Claims

0Family size

Inventors

Lorne M. Golub · Smithtown, US
Thomas F. McNamara · Port Jefferson, US
Nungavaram S. Ramamurthy · Smithtown, US
Hsi-Ming Lee · Setauket, US
Sanford Simon · Stony Brook, US
Balakrishna L. Lokeshwar · Miami, US
Marie Selzer · Fort Lauderdale, US
Norman L. Block · Miami, US

Key dates

Filing date	Jan 15, 1998
Grant date	Aug 8, 2000
Priority date	—
Expiry date	Jan 15, 2018

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.