Inhibitors of protein tyrosine kinases

US6100254A · kind A · utility

Assignees

• The Board of Regents of the University of Texas System · US
• The Regents of the University of California · US

Inventors

• Raymond J. A. Budde · Bellaire, US
• Jonathan A. Ellman · Guilford, US
• Victor Levin · Houston, US
• Gary E. Gallick · Kingwood, US
• Robert A. Newman · El Paso, US

Key dates

• Filing date: Oct 10, 1997
• Grant date: Aug 8, 2000
• Expiry date: Oct 10, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine kinases, for example pp60.sup.c-src. Methods are further provided for the use of these inhibitors in situations where the inhibition of a protein tyrosine kinase is indicated, for example, in the treatment of certain diseases in mammals, including humans.