Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6100411A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 4, 1996 |
| Grant date | Aug 8, 2000 |
| Priority date | — |
| Expiry date | Mar 4, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a taxoid of the formula (I): ##STR1## wherein R.sup.1 is a C.sub.3 -C.sub.5 alkyl or alkenyl or trifluoromethyl radical; PA1 R.sup.2 is a C.sub.3 -C.sub.5 branched alkyl radical; PA1 R.sup.3 and R.sup.4 are independently selected from hydrogen and hydroxyl protecting groups including functional groups which increase the water solubility of the taxoid antitumor agent; PA1 R.sup.5 is a hydrogen, an acyl radical, or an alkoxylcarbonyl or carbamoyl radical; and PA1 R.sup.6 is an acyl radical. The compounds of formula I are useful as antitumor agents or their precursors. This invention also relates to a pharmaceutical composition having antineoplastic activity comprising the compound of formula (I) and a physiologically acceptable carrier and method of treatment using the compound of formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.