Process for preparing a controlled release composition

US6103264A · kind A · utility

Assignee

• Arzneimittelwerk Dresden GmbH · DE

Inventors

• Torsten Hoffmann · Weil am Rhein, DE
• Klaus Liebold · Dresden, DE
• Joachim Wolf · Munich, DE
• Heiko Schumacher · Bad Oldesloe, DE

Key dates

• Filing date: Jul 7, 1998
• Grant date: Aug 15, 2000
• Expiry date: Jul 7, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2054
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for preparing a controlled release composition with a controlled release matrix and containing a pharmaceutically active ingredient, which comprises granulating the active ingredient with a molten matrix material or with a matrix material while it is being melted and with optional additional inactive materials at a first elevated temperature, then cooling and screening the granulate, forming a fluidized bed of the resulting material at a second elevated temperature, and recovering the resulting product; and the product formed by the process.