Evaluating the sensitizing/irritant/allergenic potential of a given substrate
US6103482A · kind A · utility
1Cited by
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19Claims
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Inventors
Key dates
| Filing date | Feb 11, 1998 |
| Grant date | Aug 15, 2000 |
| Priority date | — |
| Expiry date | Feb 11, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5014
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for determining the sensitizing, irritant and/or allergenic potential of a candidate substrate are provided. These methods involve simultaneously cultivating keratinocytes and Langerhans cell precursors in a nutrient medium in order to effect differentiation of the Langerhans cell precursors, and contacting the candidate substrate with the cultured cells to determine the effect if any on markers associated with sensitizing, irritant or allergenic potential.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.