Aryl imidazole compounds having phosphodiesterase IV inhibitory activity
US6103749A · kind A · utility
10Cited by
25References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1999 |
| Grant date | Aug 15, 2000 |
| Priority date | — |
| Expiry date | Apr 12, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, X.sub.1, X.sub.2 and Z are described herein. The compounds possess improved PDE IV inhibition as compared to rolipram as well as with improved selectivity with regard to PDE III inhibition. Pharmaceutical compositions containing the same and methods of treatment are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.