Anti-Cryptosporidium parvum preparations
US6110463A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Mar 27, 1997 |
| Grant date | Aug 29, 2000 |
| Priority date | — |
| Expiry date | Mar 27, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/832
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for triggering the neutralizing CSP-like reaction in the parasite. Antibodies targeted against the critical epitope were shown to possess neutralizing activity, and could be combined with other anti-C. parvum monoclonal antibodies and administered to an animal to confer passive immunity. Immunogenic compositions including the purified antigen are disclosed for use in stimulating an active immune response against C. parvum.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.