Development and use of human pancreatic cell lines
US6110743A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jun 26, 1997 |
| Grant date | Aug 29, 2000 |
| Priority date | — |
| Expiry date | Jun 26, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/206
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to cell lines, particularly mammalian cell lines, established by transforming the cells with vectors, preferably retroviral vectors, containing two or more oncogenes under the control of one or more inducible promoters and/or genetic elements. Also within the scope of the invention are human cell lines with extended in vitro lifespan, transformed by vectors containing one or more oncogenes under the control of one or more, preferably exogenous, inducible promoters and/or genetic elements. The vectors may additionally contain gene(s) encoding for desired gene product(s). Also disclosed are insulin producing human pancreatic cell lines useful for transplantation into human diabetic patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.