Antiinflammatory cell adhesion inhibitors

US6110897A · kind A · utility

Assignee

• GLYCOREX AB · SE

Inventors

• Carlo Unverzagt · Munich, DE
• Gregor Kuznik · Landsberg am Lech, DE
• Gerhard Kretzschmar · Eschborn, DE

Key dates

• Filing date: Oct 10, 1997
• Grant date: Aug 29, 2000
• Expiry date: Oct 10, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H7/027
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formula Ix and Ia: ##STR1## wherein (Ix) comprises the regioisomeric form sLe.sup.X and (Ia) comprises the regioisomeric form sLe.sup.A, and R.sup.1 is a lipophilic radical formed from aliphatic or cycloaliphatic units, or a sugar residue which is capped by a .beta.1-O-linked aliphatic or cycloaliphatic unit at the reducing end of the terminal sugar. The compounds of the present invention are useful as inhibitors of increased cell-cell adhesion as well as useful in treating diseases associated with increased cell-cell-adhesion. The compounds of the present invention are also incorporated into pharmaceutical compositions.