Benzofurazan compounds for enhancing glutamatergic synaptic responses
US6110935A · kind A · utility
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8Claims
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Key dates
| Filing date | Feb 13, 1997 |
| Grant date | Aug 29, 2000 |
| Priority date | — |
| Expiry date | Feb 13, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the general structural formula ##STR1## are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, such as memory impairment, in which AMPA receptors, or synapses utilizing these receptors, are reduced in numbers or efficiency. They may also be used to enhance excitatory synaptic activity in order to restore an imbalance between brain subregions, as in treatment of schizophrenia or schizophreniform behavior.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.