Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines

US6113914A · kind A · utility

Assignee

• SmithKline Beecham Biologicals S.A. · BE

Inventors

• Yves Lobet · Rixensart, BE
• Markus Simon · Buckenhof, DE
• Ulrich E. Schaible · Freiberg, DE
• Reinhard Wallich · Heidelberg, DE
• Michael Kramer · Freiberg, DE

Key dates

• Filing date: Jul 5, 1994
• Grant date: Sep 5, 2000
• Expiry date: Jul 5, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with known OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borrelia groups are also disclosed.