Methods of detecting T-cell activation and treating disorders associated with T-cell dysfunction
US6114129A · kind A · utility
3Cited by
2References
5Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 25, 1999 |
| Grant date | Sep 5, 2000 |
| Priority date | — |
| Expiry date | Jun 25, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/56972
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods of detecting activated T-cells involve monitoring levels of MUC-1 mucin expression at the protein and/or mRNA level. Compositions for modulating immune function contain compounds that modulate the expression or function of MUC-1. Methods of treating disorders associated an inappropriate state of T-cell activation involve contacting a T-cell with a compound containing an inhibitor of MUC-1 expression or function.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.