Method for increasing total production of 4-hydroxybenzoic acid by biofermentation
US6114157A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 25, 1998 |
| Grant date | Sep 5, 2000 |
| Priority date | — |
| Expiry date | Sep 25, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/849
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention pertains to a method of production of 4-hydroxybenzoic acid, with purification and recovery of 4-hydroxybenzoic acid directly from the fermentation medium of a cultured organism, in the presence of other chemical species. Ion exchange resin is used during the fermentation process to recover the chemical product without the necessity of separating the biomass from the fermentation supernatant by filtration after fermentation is complete and then treating the filtrate to recover the product. This reduces or eliminates the need for filtration steps and eliminates the need for energy-intensive water removal processes. Furthermore, the removal of the product during the fermentation dramatically increases the production of the product during the fermentation process. This method therefore can both increase the amount of product produced in a single fermentation run and reduce the per unit cost of its biocatalytic production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.