In-vitro detection of reactions in blood to foreign substances
US6114174A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 25, 1998 |
| Grant date | Sep 5, 2000 |
| Priority date | — |
| Expiry date | Sep 25, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N15/12
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is a method of detecting reaction in blood caused by the presence of a foreign substance in the blood, comprising the steps of: establishing a potential across a predetermined spatial volume; passing a first portion of the blood through the predetermined spatial volume; substantially continuously measuring the potential across the predetermined spatial volume over a first predetermined period of time; comparing the measured potential with a baseline; and calculating the total volume of solids in the first portion of the blood as a function of a total absolute deviation of the measured potential from the baseline. The same procedure is then followed with a second portion of the blood, after it has been exposed to the substance whose reaction is being determined. The two calculations are then compared, with a positive reaction being indicated when the two measured solid volumes are measurably different. The baselines are preferably dynamic baselines, and are determined with reference to the starting point of a sharp rise in the measured potential.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.