Methods for inhibiting the advanced glycosylation of proteins
US6114323A · kind A · utility
0Cited by
49References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 17, 1998 |
| Grant date | Sep 5, 2000 |
| Priority date | — |
| Expiry date | Dec 17, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/042
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods for inhibiting protein aging. Accordingly, methods are disclosed for treating an animal to inhibit the formation of advanced glycosylation end products of target proteins with the animal by adminstering a pharmaceutical composition comprising an agent capable of reacting with the carbonyl moiety of the early glycosylation product, whereby the subsequent cross-linking of the early glycosylation product is inhibited. Agents of the present invention comprise aminoguanidine, its pharmaceutically acceptable salts, and mixtures thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.