Anti-viral compounds

US6114327A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Steven Eugene Dunlap · Fishers, US
• Louis Nickolaus Jungheim · Indianapolis, US
• Mark J. Tebbe · Hamburg, DE
• Gilbert Thomas Voy · Indianapolis, US
• John A. Werner · Antioch, US

Key dates

• Filing date: Oct 22, 1999
• Grant date: Sep 5, 2000
• Expiry date: Oct 22, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides a series of benzimidazole compounds of formula I: ##STR1## which inhibit the growth of picornaviruses, such as rhinoviruses (bovine and human), enteroviruses such as polioviruses, coxsackieviruses of the A and B groups, or echo virus, cardioviruses such as encephalomyocarditis (EMC), apthoviruses such as foot and mouth disease virus, and flaviviruses such as hepatitis C virus and bovine viral diarrhea virus. Such compounds are also useful as intermediates for preparing additional benzimidazole antiviral compounds.