Heterocyclic compounds
US6114338A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1999 |
| Grant date | Sep 5, 2000 |
| Priority date | — |
| Expiry date | Oct 13, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds of the formula: ##STR1## wherein Y is bond or alkylene; PA1 Z is bond, alkylene or vinylene; PA1 E is PA2 (i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or bicyclic hetero ring containing as hetero atoms, one or two nitrogen atoms, one or two oxygen atoms or one sulfur atom, PA2 (ii) 4-15 membered, unsaturated or partially saturated, mono or bicyclic carbocyclic ring, or PA2 (iii) --OR.sup.4 (in which R.sup.4 is hydrogen atom, alkyl or alkyl substituted by a hydroxy group); PA1 Cyc is benzene, pyridine or imidazole; PA1 R.sup.1 is hydrogen or alkyl; PA1 R.sup.2 is hydrogen, alkyl, alkoxy or halogen atom; PA1 R.sup.3 is hydrogen, alkyl, alkoxy or --COOR.sup.5 (in which R.sup.5 is hydrogen or alkyl); with the proviso that PA1 (1) a Cyc ring should not bond to Z through a nitrogen atom in the Cyc ring when Z is vinylene and that PA1 (2) Y is not a single bond, when E is --OR.sup.4 ; or pharmaceutically acceptable acid addition salts thereof, pharmaceutically acceptable salts thereof, or hydrates thereof; have inhibitory effect on cGMP-PDE, or additionally on TXA.sub.2 synthetase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.