N-substituted azaheterocyclic compounds

US6114354A · kind A · utility

Assignee

• Novo Nordisk A/S · DK

Inventors

• Knud Erik Andersen
• Tine Krogh J.o slashed.rgensen · Avenue Madeleine, DK
• Rolf Hohlweg
• Erik Fischer · Königstein, DE
• Uffe Bang Olsen
• Zdenek Polivka · Praha, CZ
• Karel Sindelar · Praha, CZ
• Vladimir Valenta · Lučenec, SK

Key dates

• Filing date: Aug 17, 1999
• Grant date: Sep 5, 2000
• Expiry date: Aug 17, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neuragenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.