Use of inhibitors of the sodium-hydrogen exchanger for the production of a pharmaceutical for the treatment of disorders which are caused by protozoa

US6114393A · kind A · utility

Assignee

• Hoechst Marion Roussel Deutschland GmbH · DE

Inventors

• Hans-Jochen Lang · Hofheim, DE
• Michael Lanzer · Kitzingen, DE
• Jochen Wiesner · Gießen, DE
• Cecilia Sanchez · Würzburg, DE
• Stefan Wunsch · Gerbrunn, DE

Key dates

• Filing date: Aug 26, 1998
• Grant date: Sep 5, 2000
• Expiry date: Aug 26, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of the sodium-hydrogen exchanger are suitable on their own or in combination with other classes of active compound for the production of a medicament for the treament of diseases which are caused by protozoa; thus of diseases which are caused by animal- and human-pathogenic protozoa, such as by intracellularly active parasites of the classes Apicomplexa and Zoomastigophorea, in particular trypanosomes, plasmodia (malaria pathogens), leishmanias, babesias and theilerias, cryptosporidiidae, sarcocystidae, amoebae, coccidia and trichomonads. NHE inhibitors are particularly preferably suitable for the production of a medicament for the treatment of tropical malaria, of tertian malaria, of quartan malaria, as well as toxoplasmosis, of coccidiosis, of intestinal sarcosporidosis, of cryptosporidosis, of Chargas' disease and of the cutaneous and visceral as well as other forms of leishmaniases; and also for the production of a medicament for the treatment of animals which have been infected by animal-pathogenic protozoa, such as by Theileria parva, the pathogen of East Coast fever of cattle, Babesia begemina, the pathogen of Texas fever in cattle and buffalo, Babesia bovis, the …