Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals

US6114532A · kind A · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Uwe Ries · Biberach an der Riß, DE
• Norbert Hauel · Schemmerhofen, DE
• Gerhard Mihm · Biberach, DE
• Henning Priepke · Warthausen, DE
• Klaus Binder · Warthausen, DE
• Jean-Marie Stassen · Bad Buchau, DE
• Wolfgang Weinen · Biberach, DE
• Rainer Zimmerman · Mittelbiberach, DE

Key dates

• Filing date: Feb 2, 1999
• Grant date: Sep 5, 2000
• Expiry date: Feb 2, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65068
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula ##STR1## wherein R.sub.a to R.sub.c, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. The compounds of the above formula I wherein R.sub.c denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein R.sub.c denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.