Method of making a perorally administered solid drug with controlled effective ingredient delivery

US6117450A · kind A · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Michael Dittgen · Apolda, DE
• Sabine Fricke · Jena, DE
• Carsten Timpe · Bad Birnbach, DE
• Hagen Gerecke · Jena, DE
• Annette Eichardt · Jena, DE

Key dates

• Filing date: Apr 24, 1998
• Grant date: Sep 12, 2000
• Expiry date: Apr 24, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The method of making a solid drug with controlled effective ingredient delivery for oral administration includes selecting a predetermined number of at least three of four compressed compositions containing an effective ingredient or effective ingredient combination defined by their release profile of effective ingredient and/or effective ingredient combination. The solid drug or medicinal preparation is formed according to known methods requiring only comparatively small apparatus expense and minimal time. Perorally administered solid drugs are made by this process which can provide widely varying pharmaceutically-required release profiles of effective ingredients or effective ingredient combinations, for example delayed release, uniformly maintained release or pulsatile release adjusted to fit a special rhythm.