Crystal of a Ras-Sos complex
US6117663A · kind A · utility
2Cited by
0References
10Claims
0Family size
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Key dates
| Filing date | Jul 19, 1999 |
| Grant date | Sep 12, 2000 |
| Priority date | — |
| Expiry date | Jul 19, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/47
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit tumor proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.