6,8-dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical and pharmaceutical compositions intended for the treatment of cancerous tumors
US6117902A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 30, 1999 |
| Grant date | Sep 12, 2000 |
| Priority date | — |
| Expiry date | Mar 30, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C327/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides 6,8-Dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical, wherein they correspond to the following formula (I): ##STR1## in which: R represents OR.sub.3 or ##STR2## R.sub.3 representing a hydrogen atom, a linear or branched alkyl radical, or a radical of the formula ##STR3## n being an integer from 1 to 10 and r' and r", which are identical or different, representing a hydrogen atom, a linear or branched alkyl radical or, taken together, form with the nitrogen atom, a nitrogen-containing heterocycle optionally substituted with an optionally substituted oxygen or nitrogen atom, PA1 R.sub.5 and R.sub.4, identical or different, represent a hydrogen atom or a linear or branched alkyl radical, PA1 R.sub.1 and R.sub.2, which are identical or different, represent a hydrogen atom, a radical --COCH.sub.3 or a radical of formula: EQU --CO(CH.sub.2).sub.2 SCH.sub.3 (II) PA1 with the proviso that at least one of the radicals R.sub.1 or R.sub.2 represents a radical of formula (II) and the R and S enantiomers and their racemate as well as the salts of the said compounds of formula (I). The present i…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.