Conjugates of microbeads and antibodies specific for T lymphocytes and their use as in vivo immune modulators
US6117982A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 8, 1993 |
| Grant date | Sep 12, 2000 |
| Priority date | — |
| Expiry date | Apr 8, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Several forms of immunoregulatory substances are derived from monoclonal antibodies (MAbs) that are specific for a T cell surface antigen, such as CD3, TCR, CD4, or CD8 on T cells. The substances include: a mixture of F(ab').sub.2 fragments (or other divalent binding molecules which lack Fc) which each bind noncompetitively to different monovalent antigenic epitopes on the same antigen; a conjugate including a polymer molecule, such as dextran, ficoll, or agarose, that is coupled with the binding molecules, e.g., Fv, Fab, or F(ab').sub.2, which bind to monovalent antigenic epitopes on the same antigen on T cells; a conjugate including a liposome or microbead that is coupled with the same binding molecules specific for a T cell surface antigen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.