Lysosomal proteins produced in the milk of transgenic animals
US6118045A · kind A · utility
90Cited by
2References
20Claims
0Family size
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Key dates
| Filing date | Jul 29, 1996 |
| Grant date | Sep 12, 2000 |
| Priority date | — |
| Expiry date | Jul 29, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S119/01
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.