Isolated human cytomegalovirus polypeptides and uses thereof

US6120989A · kind A · utility

Assignee

• Biotest AG · DE

Inventors

• Rolf Vornhagen · Langen, DE
• Walter Hinderer · Rodgau, DE
• Hans H. Sonneborn · Heusenstamm, DE
• Bodo Plachter · Wörrstadt, DE
• Gerhard Jahn · Neunkirchen, DE

Key dates

• Filing date: Jul 25, 1995
• Grant date: Sep 19, 2000
• Expiry date: Jul 25, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/975
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Diagnostically relevant polypeptides and fusion proteins comprising an amino acid sequence which originates from cytomegalovirus and corresponds to a region of the major DNA-binding protein or of the C-terminal region of the tegument protein pp150 fused with at least one further fragment from another antigenic protein of cytomegalovirus are disclosed. The major DNA-binding protein is encoded by the reading frame UL57. The poly-peptides and fusion proteins according to the invention can be used in an advantageous manner in diagnostic tests and methods for the detection of IgM antibodies against cytomegalovirus.