Method to detect bone and other connective tissue disorders in humans and animals
US6121002A · kind A · utility
7Cited by
4References
19Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 6, 1995 |
| Grant date | Sep 19, 2000 |
| Priority date | — |
| Expiry date | Jun 6, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/108
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free collagen-derived crosslinks in biological fluids, especially urine. The method can be enhanced by concomitantly determining the levels of an indicator of bone formation in biological fluids of the same individual and assessing the differences between the degradation marker and the formation indicator. Antibodies which are specifically immunoreactive with forms of crosslinks which occur free in biological fluids are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.