Process for producing optically active 3-quinuclidinol derivatives
US6121025A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 5, 1999 |
| Grant date | Sep 19, 2000 |
| Priority date | — |
| Expiry date | May 5, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/939
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a process for producing optically active 3-quinuclidinol or derivatives, wherein a racemic 3-quinuclidinol ester represented by the general formula (I): ##STR1## wherein R represents a straight-chain or branched alkyl group, and (H.sup.+) represents that said ester may be in the form of a salt formed with a mineral acid or an organic acid, is reacted with a microorganism belonging to the genus Aspergillus, Rhizopus, Candida or Pseudomonas having the ability to asymmetrically hydrolyze said ester linkage, a culture of said microorganism, a treated material from said microorganism, an enzyme produced by said microorganism, or an enzyme derived from swine or cattle. According to the present invention, there is provided a process for easily producing optically active 3-quinuclidinol derivatives which are important synthetic intermediates for pharmaceutical preparations etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.