Peptide substrates for the identification of factor Xa
US6121239A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 18, 1991 |
| Grant date | Sep 19, 2000 |
| Priority date | — |
| Expiry date | Oct 18, 2011 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96444
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Peptide substrates selected from the group consisting of (i) the tri- and tetra-peptides of the formula EQU Q-A.sub.1 -A.sub.2 -Gly-A.sub.4 -R (I) having SEQ ID NO: 1 in which Q is a group which blocks the N-termnal end of the peptide chain, A.sub.1 is selected from the group consisting of Leu, Ile, Nle, Nva, CHA, CHG, CHT, Phe, Ala and Lys groups, where the basic side-group of the Lys residue is blocked with a suitable group which substantially removes the basic character of said side-group, A.sub.2 is a single bond, Asp or Glu, the carboxylic acid side-group of Asp and Glu being capable of esterification or amidation, A.sub.4 is selected from the group consisting of Arg and Lys groups, and R is pNA; and (ii) their addition salts. These peptide substrates are useful in the determination of Factor Xa.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.