Epoxide-containing compounds

US6121270A · kind A · utility

Assignee

• CELLO THERAPEUTICS, INC. · US

Inventors

• Gail E. Underiner · Malvern, US
• J. Peter Klein · Vashon, US
• John Michnick · Seattle, US
• Alistair J. Leigh · Edmonds, US
• Anil Kumar · Seattle, US

Key dates

• Filing date: Jun 17, 1998
• Grant date: Sep 19, 2000
• Expiry date: Jun 17, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are enantiomers diastereomers, salts, solvates, hydrates and mixtures thereof, of formula I: ##STR1## The core moiety is non-cyclic or at least one five- to seven-membered ring, n is an integer from about 4 to about 16, R.sub.1 and R.sub.2 are hydrogen, halogen or C.sub.1-12 alkyl or alkenyl, and (CH.sub.2).sub.n may be substituted by a hydroxyl, halogen, oxygen, a (C.sub.1-4) alkyl group or a dimethylamino group. The compounds and pharmaceutical composition thereof are useful in methods for treating an individual having a disease or treatment-induced toxicity, mediated by second messenger activity.