Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity

US6121278A · kind A · utility

Assignee

• Guilford Pharmaceuticals, Inc. · US

Inventors

• Paul F. Jackson · Bel Air, US
• Keith M. Maclin · Baltimore, US
• Jie Zhang · Beijing, CN

Key dates

• Filing date: Sep 1, 1998
• Grant date: Sep 19, 2000
• Expiry date: Sep 1, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula I: ##STR1## or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: Y represents the atoms necessary to form a fused 5- to 6-membered, aromatic or non-aromatic, heterocyclic ring containing at least one nitrogen heteroatom in a 1,3-relationship with the nitrogen atom depicted in formula I, wherein Y may be unsubstituted or substituted with at least one alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl, aryl, double bonded oxygen, or --COOR.sup.5 group, or a moiety selected from the group consisting of: ##STR2## wherein R.sup.5 and R.sup.7 are independently hydrogen or alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl, or aryl.