Disubstituted bicyclic heterocycles, the preparation thereof and their use as pharmaceutical compositions

US6121308A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Norbert Hauel · Schemmerhofen, DE
• Uwe Ries · Biberach an der Riß, DE
• Henning Priepke · Warthausen, DE
• Gerhard Mihm · Biberach, DE
• Wolfgang Wienen · Äpfingen, DE
• Jean-Marie Stassen · Bad Buchau, DE
• Klaus Binder · Warthausen, DE
• Rainer Zimmermann · Mittelbiberach, DE

Key dates

• Filing date: Jul 22, 1999
• Grant date: Sep 19, 2000
• Expiry date: Jul 22, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel disubstituted bicyclic heterocycles, of which the following are exemplary: PA1 (a) 1-methyl-2-[(4-amidinophenyl)-oxymethyl]-5-[N-(hydroxycarbonylmethyl)-quin oline-8-sulphonylamino]-benzimidazole, PA1 (b) 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(N-(hydroxycarbonylmethyl)-ami nocarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole, PA1 (c) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)- quinoline-8-sulphonylamino]-benzimidazole and PA1 (d) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)- quinoline-8-sulphonylamino]-indole. These are useful for the treatment of thrombotic disease.