Reshaped human antibody to human interleukin-6
US6121423A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 4, 1998 |
| Grant date | Sep 19, 2000 |
| Priority date | — |
| Expiry date | Dec 4, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A reshaped antibody comprising: PA1 (A) L chains comprising: PA2 (1) a human C region, and PA2 (2) an L chain V region comprising human L chain FRs and L chain CDRs of a mouse monoclonal antibody; and PA1 (B) H chains comprising: PA2 (1) a human H chain C region, and PA2 (2) an H chain V region comprising human H chain FRs, and H chain CDRs of a mouse monoclonal antibody to human IL-6. Since the major portions of the reshaped human antibody are derived from human, and the mouse CDRs are less immunogenic, then the present reshaped human antibody is less immunogenic, and therefore inhibits information transfer by IL-6, and is promising as a therapeutic agent for diseases caused by IL-6.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.