Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein

US6121489A · kind A · utility

Assignee

• Trega Biosciences, Inc. · US

Inventors

• Barbara Dorner · Basel, CH
• John M. Ostresh · Encinitas, US
• Colette T. Dooley · San Diego, US
• Richard A. Houghten · Del Mar, US
• Jutta Eichler · Berlin, DE

Key dates

• Filing date: Mar 5, 1997
• Grant date: Sep 19, 2000
• Expiry date: Mar 5, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The instant invention is directed to a single, selectively N-alkylated compound and libraries of such compounds as set forth in Formula I. Furthermore, the instant invention is directed to methods of effecting analgesia, a decrease in the postprandial rise in the blood glucose levels of a mammal after ingestion of a carbohydrate load by said mammal, and treating microbial infections, utilizing such a single compound of Formula I in conjunction with a pharmaceutically-acceptable carrier. Also, the instant invention is directed to methods for selective alkylation, positional scanning and iterative synthetic and screening technologies.