Superparamagnetic contrast media coated with starch and polyalkylene oxides

US6123920A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Wolfgang H. H. Gunther · Hersbruck, DE
• Dennis Fujii · Downingtown, US
• Kenneth Kellar · Wayne, US
• Christopher Black · Norristown, US
• Vinay C. Desai · Phoenixville, US
• Marshal Beeber · Wayne, US
• Jennifer Wellons · Wayne, US
• Anne Kjersti Fahlvik · Oslo, NO
• Anne N.ae butted.vestad · Oslo, NO

Key dates

• Filing date: Oct 15, 1996
• Grant date: Sep 26, 2000
• Expiry date: Oct 15, 2016

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.