Compositions and methods for controlling genetically engineered organisms
US6124129A · kind A · utility
1Cited by
2References
5Claims
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Key dates
| Filing date | Feb 6, 1998 |
| Grant date | Sep 26, 2000 |
| Priority date | — |
| Expiry date | Feb 6, 2018 |
Classification
- Technology area (CPC —)General
Abstract
Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin. The general requirement for biotin through the living world makes streptavidin-based conditional lethal designs applicable to a broad range of containment strategies.
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