Use of N-(substituted glycyl)-2-cyanopyrrolidines in inhibiting dipeptidyl peptidase-IV
US6124305A · kind A · utility
73Cited by
4References
10Claims
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Key dates
| Filing date | Oct 20, 1999 |
| Grant date | Sep 26, 2000 |
| Priority date | — |
| Expiry date | Oct 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## wherein R is as defined herein. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.