4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

US6124323A · kind A · utility

Assignees

• WARNER-LAMBERT COMPANY LLC · US
• Cocensys, Incorporated · US

Inventors

• Christopher Franklin Bigge · Ann Arbor, US
• Po-Wai Yuen · Ann Arbor, US
• Sui Xiong Cai · San Diego, US
• Eckard Weber · San Diego, US
• Richard Woodward · Phoenixville, US
• Nancy C. Lan · Altadena, US
• Zhang-Lin Zhou · Irvine, US
• John F. W. Keana · Eugene, US
• Anthony P. Guzikowski · Eugene, US

Key dates

• Filing date: Sep 16, 1998
• Grant date: Sep 26, 2000
• Expiry date: Sep 16, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.