Processes for making and using alkylaminoarylcarbonyl compounds
US6124503A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 31, 1998 |
| Grant date | Sep 26, 2000 |
| Priority date | — |
| Expiry date | Dec 31, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of making an alkylaminoarylcarbonyl compound having Formula I: ##STR1## wherein R is an alkyl group; PA1 A is an aryl (including heteroaryl) ring; PA1 each R' is independently an alkyl group which may form a ring with Z or Z'; PA1 p is 0, 1, 2, or 3; PA1 each Z, Z', and Y is independently hydrogen or a substituent; and PA1 n is 0, 1, or 2; comprising: PA1 (a) blocking the carbonyl function of an aminoarylcarbonyl compound via condensation with an active methylene compound PA1 (b) alkylating this blocked amniocarbonyl compound via reductive alkylation with an alkyl or aryl (including heteroaryl) carbonyl compound, and PA1 (c) deblocking of the blocked alkylaminoarylcarbonyl compound via base hydrolysis to regenerate the carbonyl function and give the desired alkylaminocarbonyl compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.