Process for producing nucleoside derivatives
US6127152A · kind A · utility
2Cited by
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4Claims
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Key dates
| Filing date | Jul 30, 1998 |
| Grant date | Oct 3, 2000 |
| Priority date | — |
| Expiry date | Jul 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/40
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
There is disclosed a process for producing a nucleoside derivative of the formula [I]: ##STR1## characterized by contacting 2',3',5'-O-triacylribonucleoside derivative of the formula [II]: ##STR2## with an ester hydrolase: (i) capable of regio-selectively deacylating the acyl group at 5'-O-position in the formula [II] above, and PA1 (ii) having an amino acid sequence encoded by a gene which hybridizes to a nucleotide sequence encoding an amino acid sequence of SEQ ID NO:1.
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