Apoptotic peptides

US6127178A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Mark A. Israel · Amherst, US
• Monica Florio · Thousand Oaks, US

Key dates

• Filing date: Mar 20, 1998
• Grant date: Oct 3, 2000
• Expiry date: Mar 20, 2018

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Apoptosis-promoting recombinant Id polypeptides comprise an Id N-terminus domainpeptides comprise an Id N-terminus domain peptide comprising an effective portion of the N-terminal domain of a natural Id protein. The polypeptides may be produced recombinantly from transformed host cells from the subject recombinant Id polypeptide encoding nucleic acids. The invention provides methods of making and using the subject compositions and mimic thereof to modulate cellular physiology, and especially promote apoptosis and in the biopharmaceutical industry.